Dive Into a New Age of Biosensing Technology
Did you know that besides containing the blue-print to most life forms, nucleic acids are molecules that are able to adopt complex 3D structures? These structures give them the ability to bind strongly to a wide array of targets in a selective manner. Nucleic acids structures with such binding abilities are called aptamers.
Besides target recognition and binding , there is a specific class of these nucleic acids that are able to simultaenously bend or cleave DNA and RNA (aptazymes) ,which then allows for allosteric gene expression and regulation (riboswitches).
Our platform allows an efficient high-throughput production of these powerful molecular tools in a customized manner, in order to provide our clients the tools needed to detect their target of choice, and ,if desired, alter their sequence or gene of interest.
More versatile than conventional bioreceptors
Easy to integrate and adapt onto any working instrumentation and platform.
The reason to that is relying on the dynamic properties of our tailored bioreceptors. The event of the target binding will induce a conformational switch (see Fig. 1), that could be either a structural change or even an auto-cleavage of the bioreceptor. Thus, we have, with our bioreceptors, target recognition systems that translate the event of the detection into a physical change.
In other words, unlike the conventional static bioreceptors, we have here a bioreceptor that offers a double function: the target recognition AND the translation of this event into a physical manifestation.
The liberation (conformational switch) or the release (auto-cleavage) of a segment of the bioreceptor that occurs when the target is recognized, can be easily used as a trigger of various signalisation systems (RCA, LAMP, ToeHold, Fluorescent beacon/Quencher based signal, etc.). That’s the reason why we can affirm without restraint that our biocaptors open many different doors in addition to their shared properties with the conventional static systems.
Bioreceptors that are able to couple target recognition to gene expression regulation
Better yet, with some minor design retouch our bioreceptors can become tools which subsequent to target recognition able to cleave distanced (action in trans) specific mRNA sequences.
Which means that we can couple target identification with the expression regulation of a gene of choice, which offer a bunch of totally new avenues in applications (see next section “Multiple Application Uses“)
High Sensitivity level
The in vitro procedure permitting the production of our bioreceptors allows to introduce negative selection cycles to eliminate the candidates that present affinity to counter-targets. Thus, we are able to fine-tune the specificity of the final product in order to select only candidate that doesn’t present any cross-reaction risk.
Bioreceptors molded during their production process according to the conditions where they will operate
Another advantage of a totally in vitro production system is that our bioreceptors are forged directly in the conditions where they are meant to be used later on. Since the selection is done in the under chosen conditions during the production process there is no question about the capacity of our bioreceptors to function in the intended conditions.
Multiple Application Uses
Our bespoke bioreceptors, with their capabilities cited above, can be used in a range of applications.
Their usefulness go beyond the scope of conventional bioreceptors and include some unique utilities. Here is the (non-exhaustive) list of the major context where our bioreceptor can serve their user as no other biotool:
Develop advanced technologies for highly specific and sensitive target recognition systems adaptable to all types of detection and diagnostic platforms.
Develop multi-parametric reliable and highly precise targeted therapy systems for localized, tissue, cell-type or pathogen specific therapeutics delivery/activation
Increase production capacity of biomaterial (target recognition to gene regulation )
Fine-tune metabolic engineering
High-throughput screening/selection of strains with desired characteristics
Transform the desired effect’s outcomes into selection pressure parameters to be able to establish versatile, efficient and accelerated directed evolution systems (DES) for every purpose (even the ones considered until now DES-incompatible)
Enables live imaging when target have no specific external markers
Change the way you look at bioreceptors , reporters or labelling technologies
Our high-throughput platform enables the identification of a suite of bioreceptors, that can interact with multiple sites on your target, allowing you to get a clearer picture of your target properties and more functionality.
When you order from us, biocaptors towards a given target we offer you a “smart cocktail” of biocaptors that will recognize either different epitopes of you target or different components included in your target mix, if it’s a multi-component target. This allows clearly to reach an increased sensitivity level in compared to conventional approach which is using a single bioreceptor (like the use of monoclonal antibodies). In addition, our technology doesn’t have any batch-to-batch variation or reproducibility issues that is present the polyclonal antibodies.
Committed Customer Service Team
Our success relies on your success. Our team of experts are dedicated to helping you to find solutions to your specific project needs.
When you use our services , we commit to offer you the complete dedication of our scientific team, in order to assure a good comprehension of your needs and a well-adapted service. More precisely our services include multiple common “brain-storming” sessions, around the question of “How best we can serve your needs?”